Chromatin and disease
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Chromatin and disease

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Published by Springer in New York .
Written in English

Subjects:

  • Chromatin.,
  • Epigenesis.,
  • Drug targeting.,
  • Chromatin -- pathology.,
  • Chromatin -- genetics.,
  • Chromatin -- physiology.,
  • Histones -- therapeutic use.,
  • Histones -- physiology.,
  • Epigenesis, Genetic.

Book details:

Edition Notes

Includes bibliographical references and index.

Statementedited by Tapas K. Kundu and Dipak Dasgupta.
SeriesSubcellular biochemistry -- v. 41.
ContributionsKundu, Tapas K., Das Gupta, Dipak.
The Physical Object
Paginationxiii, 433 p., [22] p. of plates :
Number of Pages433
ID Numbers
Open LibraryOL18286267M
ISBN 101402054653
ISBN 109781402054655

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The book has been divided into three different parts. Part I introduces the reader to the dynamic nature of chromatin structure and its link to diseases. First two chapters in this part deal with the chromatin architecture, chromatin dynamics in the cell cycle and molecular mechanism of chromatin remodeling. Chromatin and Disease (Subcellular Biochemistry) th Edition by Tapas K. Kundu (Editor), Dipak Dasgupta (Editor) ISBN ISBN Why is ISBN important? ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. Format: Hardcover. This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. The book contains up-to-date information . Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin.

Chromatin Signaling. and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer.. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of. Get this from a library! Chromatin and disease. [Tapas K Kundu; Dipak Dasgupta;] -- It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena. Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining Brand: Elsevier Science. Chromatin is composed of DNA and histones that are packaged into thin, stringy fibers. These chromatin fibers are not condensed but can exist in either a compact form (heterochromatin) or less compact form (euchromatin). Processes including DNA replication, transcription, and recombination occur in Author: Regina Bailey.

Chromatin structure is hierarchic, ranging from the two lowest levels of DNA packaging – the nucleosome and the 30 nm chromatin fiber (see Figures and ) – to the metaphase chromosomes, which represent the most compact form of chromatin in eukaryotes and occur only during nuclear division. After division, the chromosomes become less Cited by: 1. Most, if not all, of the DNA is present in chromatin, which is a complex of DNA with an equal weight of basic proteins called histones. Histones are small proteins which are basic because they have a high content of arginine or lysine The four fundamental histones, H2A, H2B, H3, and H4, are present twice.   Chromatin immunoprecipitation (ChIP) is an important technique to study protein–DNA interactions in vivo. Chemical cross-linking of DNA and its associated proteins, followed by chromatin shearing, immunoprecipitation of a protein of interest, DNA isolation, and PCR interrogation, can identify specific interactions between protein and DNA or. The book covers the different aspects from basic science to available technology and highlights the significant impact of epigenomics on the understanding of human disease. Epigenetic abnormalities are very critical in the pathogenesis of human cancer; the understanding of epigenetics is of importance for the development of innovative Format: Paperback.